Parit

Uses
Every tablet of Parit (Rabeprazole) contains 20mg of the active medical compound, Rabeprazole sodium.

Parit (Rabeprazole) is classified as an anti-ulcer medication, H+/K+-ATPase inhibitor, i. e. it affects H+/K+-ATPase enzyme, which is produced in the parietal cells of the stomach, and acts as a proton pump inhibitor. As a result, the active medical compound blocks the generation of hydrochloric acid in the final stage, as well as reduces the stimulation of its production irrespective of the type of the stimulus.

After the administration of 20mg of Parit (Rabeprazole), it is completely absorbed within around 3.5 hours. Bio availability of the active ingredient as well as absorption qualities of the medication don’t depend on the time of administration.

Parit (Rabeprazole) is used to treat the following disorders:

• Duodenal ulcer, including the exacerbation phase;
• Pathological hypersecretory conditions;
• Gastroesophageal reflux disease;
• Stomach ulcers;
• Zollinger-Ellison syndrome;
• Gastritis (Helicobacter pylori eradication), including chronic gastritis (combined with the antibiotics);
• Ulcer disease relapses, caused by Helicobacter pylori.

Dosage and Administration
Tablets, containing the active ingredient, are taken by mouth. The treatment regimen and the dosage depend on the type and severity of the disease and on the condition of the patient. The recommended initial dose is 10-20mg.

Side effects
The administration of Parit (Rabeprazole) may cause side effects, associated with gastro-intestinal tract, respiratory system, nervous system, and musculo-skeletal system, such as:

• Diarrhea, decreased appetite, stomatitis, vomiting, nausea, constipation, dry mouth, elevated liver transaminases, flatulence;
• Dizziness, asthenia, drowsiness, vision and taste disorders, headache;
• Leucopenia, thrombocytopenia;
• Cramps, muscle pain, joint pain;
• Sinusitis, pharyngitis, cough, rhinitis;
• Back pain;
• Fever;
• Allergic reaction in the form of skin rash.

When such side effects as drowsiness and fatigue occur, the patients should avoid driving motor vehicles or performing other activities requiring alertness.

Precautions
Before starting the medical treatment with Parit (Rabeprazole), it is required to rule out malignant tumors in the gastrointestinal tract organs, as long as using this medication may cover the symptoms and complicate the timely diagnosis of cancer.

Parit (Rabeprazole) should be used with caution in patients with liver disorders. When it is combined with Digoxin and Ketoconazole, the dosage of the latter two should be adjusted.

The absolute contraindications for Parit (Rabeprazole) are pregnancy, breast feeding, hypersensitivity to the components of the drug, usually to Rabeprazole or substituted Benzimidazole.