Daclahep (Daclatasvir Dihydrochloride) - 60mg (28 Tablets)

Daclahep

DACLATASVIR (AS DIHYDROCHLORIDE)

* Our best price : £ 249.61

Daclahep (Daclatasvir Dihydrochloride) is used alongside sofosbuvir and/or ribavirin to treat chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infection.

Brand Name : Daclahep
Active Ingredients : DACLATASVIR (AS DIHYDROCHLORIDE)
Manufacturer : Hetero
Country of Origin : India
Intended Patient : Unisex
Daclahep (Daclatasvir Dihydrochloride) - 60mg (28 Tablets) Daclahep (Daclatasvir Dihydrochloride) - 60mg (28 Tablets)
Out of stock
* Quantity
1 Bottle +
Price / Each
£249.61

Description


Main Use Active Ingredient Marketed Name
Chronic Hepatitis C infection Daclatasvir Dihydrochloride Daclahep

Uses
Daclahep (Daclatasvir Dihydrochloride) is used alongside sofosbuvir and/or ribavirin to treat chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infection.

Dosage and Administration
The recommended dosage in most people is one 60mg tablet taken each day for a period of 12 weeks.

Daclahep should always be taken with Sofosbuvir or with Sofosbuvir and Ribavirin according to the following guidelines:

  • Genotype 1 infection with no cirrhosis - daclatasvir + sofosbuvir
  • Genotype 1 infection with compensated cirrhosis - daclatasvir + sofosbuvir
  • Genotype 1 infection with decompensated cirrhosis - daclatasvir + sofosbuvir + ribavirin
  • Genotype 1 infection post-transplant - daclatasvir + sofosbuvir + ribavirin
  • Genotype 3 infection with no cirrhosis - daclatasvir + sofosbuvir
  • Genotype 3 infections with compensated cirrhosis - daclatasvir + sofosbuvir + ribavirin
  • Genotype 3 infections with decompensated cirrhosis - daclatasvir + sofosbuvir + ribavirin
  • Genotype 3 infection post-transplant - daclatasvir + sofosbuvir + ribavirin

Side effects
The most common side effects encountered when taking Daclatasvir and Sofosbuvir are headache, fatigue, nausea and diarrhea.

When Ribavirin is also taken, patients have also reported anemia, rash, insomnia, dizziness and somnolence as side effects.

Precautions
Patients who are taking Amiodarone with Daclahep and Sofosbuvir may experience serious symptomatic bradycardia, especially if they are taking beta-blockers or have heart problems or liver disease.

Daclatasvir is should not be taken alongside when taking strong inducers of CYP3A such as phenytoin, carbamazepine, rifampin, and St. John’s wort.

Some medicines interact with Daclatasvir. You may need to be monitored carefull if you taker any of the following with daclatasvir:

  • Protease inhibitors (atazanavir with ritonavir, indinavir, nelfinavir, saquinavir)
  • Other antiretrovirals (eg. atazanavir/cobicistat, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate)
  • Non-nucleoside reverse transcriptase inhibitors (efavirenzb, etravirine, nevirapine)
  • Strong CYP3A inhibitors (eg. clarithromycin, itraconazole, ketoconazole, nefazodone, posaconazole, telithromycin, voriconazole)
  • Moderate CYP3A inducers (eg. bosentan, dexamethasone, modafinil, nafcillin, rifapentine)
  • Anticoagulants (dabigatran etexilate mesylate)
  • Cardiovascular agents (Amiodarone, Digoxin)
  • HMG-CoA reductase inhibitors (Atorvastatin, Fluvastatin, Pitavastatin, Pravastatin, Rosuvastatin, Simvastatin)
  • Narcotic Analgesics (buprenorphine, buprenorphine/naloxone)

Daclatasvir may increase the risk of birth defects and miscarriage. Before taking daclatasvir, tell your doctor if:

  • you are pregnant, trying to become pregnant or breast-feeding
  • your partner is pregnant or trying to become pregnant

Safety of Daclatasvir in patients under 18 years has not been established.

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