Pirfenex 200mg

PIRFENIDONE

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Pirfenex (Pirfenidone) is an immunosuppressant used to treat mild or moderate pulmonary fibrosis in adults. Currently, the mechanism of action of Pirfenex (Pirfenidone) is not fully established. However, modern data indicate that Pirfenex (Pirfenidone) exhibits antifibrosis and anti-inflammatory properties in many in vitro systems and in animal models of pulmonary fibrosis (fibrosis induced by bleomycin and transplantation).

Brand Name : Pirfenex 200mg
Active Ingredients : PIRFENIDONE
Manufacturer : Cipla
Country of Origin : India
Intended Patient : Unisex

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Pirfenex 200mg (Pirfenidone) - 200mg (2 x 15 Tablet)
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Description


Main Use Active Ingredient Marketed Name
Idipathic pulmonary fibrosis (IPF) Pirfenidone Pirfenex

Uses
Pirfenex (Pirfenidone) is an immunosuppressant used to treat mild or moderate pulmonary fibrosis in adults.

Currently, the mechanism of action of Pirfenex (Pirfenidone) is not fully established. However, modern data indicate that Pirfenex (Pirfenidone) exhibits antifibrosis and anti-inflammatory properties in many in vitro systems and in animal models of pulmonary fibrosis (fibrosis induced by bleomycin and transplantation).

Dosage and Administration
Pirfenex (Pirfenidone) is for oral use. The capsule should be swallowed whole, washed with water, and taken with food in order to reduce the probability of occurrence of vomiting and dizziness.

After starting treatment, the dose of the drug should be titrated for 14 days until the recommended daily dose is reached. The dosage and multiplicity of the Pirfenex (Pirfenidone) is prescribed by the physician.

Side effects
The most frequent adverse effects during the pirfenidone clinical study at the maximum dose were nausea, rash, diarrhea, fatigue, dyspepsia, anorexia, headache and photosensitivity reactions. Contact your doctor immediately if you experience any serious or worrying symptoms.

Precautions
Use during pregnancy and lactation

There are no data on the use of pirfenidone in pregnant women.

In animals, pirfenidone and / or its metabolites are transferred through the placenta with possible accumulation of pirfenidone and / or its metabolites in the amniotic fluid. With the introduction of high doses (≥1000 mg / kg / day) in rats, gestation is prolonged and the viability of the fetus is reduced.

Pirfenidone use during pregnancy is contraindicated.

It is not known whether pyrfenidone or its metabolites in breast milk is excreted. Available pharmacokinetic data in animals showed excretion of pirfenidone and / or its breast milk metabolites and the possibility of accumulation of pirfenidone and / or metabolites in milk. Risk to infants cannot be excluded.

The decision to discontinue breastfeeding or the appointment of pirfenidone should be made taking into account the benefits of breastfeeding for the child and the benefits of therapy for the mother.

Fertility. In the course of preclinical studies of adverse effects on fertility was not observed.

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